Here you can find a consolidated (a.k.a. slowly updated) list of my publications. A frequently updated (and possibly noisy) list of works is available on my Google Scholar profile.
Please find below a short list of highlight publications for my recent activity.
S, Fernandes Ana; Davide, Bacciu; H, Jarman Ian; A, Etchells Terence; M, Fonseca Jose; JG, Lisboa Paulo Different Methodologies for Patient Stratification Using Survival Data Conference Lecture Notes in Computer ScienceComputational Intelligence Methods for Bioinformatics and Biostatistics, vol. 6160, 2010. Davide, Bacciu; H, Jarman Ian; A, Etchells Terence; G, Lisboa Paulo J Patient stratification with competing risks by multivariate Fisher distance Conference 2009 International Joint Conference on Neural Networks, IEEE, 2009.@conference{11568_465483,
title = {Different Methodologies for Patient Stratification Using Survival Data},
author = {Fernandes Ana S and Bacciu Davide and Jarman Ian H and Etchells Terence A and Fonseca Jose M and Lisboa Paulo JG},
doi = {10.1007/978-3-642-14571-1_21},
year = {2010},
date = {2010-01-01},
booktitle = {Lecture Notes in Computer ScienceComputational Intelligence Methods for Bioinformatics and Biostatistics},
journal = {LECTURE NOTES IN COMPUTER SCIENCE},
volume = {6160},
pages = {276--290},
abstract = {Clinical characterization of breast cancer patients related to their risk and profiles is an important part for making their correct prognostic assessments. This paper first proposes a prognostic index obtained when it is applied a flexible non-linear time-to-event model and compares it to a widely used linear survival estimator. This index underpins different stratification methodologies including informed clustering utilising the principle of learning metrics, regression trees and recursive application of the log-rank test. Missing data issue was overcome using multiple imputation, which was applied to a neural network model of survival fitted to a data set for breast cancer (n=743). It was found the three methodologies broadly agree, having however important differences.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
@conference{11568_465484,
title = {Patient stratification with competing risks by multivariate Fisher distance},
author = {Bacciu Davide and Jarman Ian H and Etchells Terence A and Lisboa Paulo J G},
doi = {10.1109/IJCNN.2009.5179077},
year = {2009},
date = {2009-01-01},
urldate = {2009-01-01},
booktitle = {2009 International Joint Conference on Neural Networks},
pages = {3453--3460},
publisher = {IEEE},
abstract = {Early characterization of patients with respect to their predicted response to treatment is a fundamental step towards the delivery of effective, personalized care. Starting from the results of a time-to-event model with competing risks using the framework of partial logistic artificial neural networks with automatic relevance determination (PLANNCR-ARD), we discuss an effective semi-supervised approach to patient stratification with application to Acute Myeloid Leukaemia (AML) data (n = 509) acquired prospectively by the GIMEMA consortium. Multiple prognostic indices provided by the survival model are exploited to build a metric based on the Fisher information matrix. Cluster number estimation is then performed in the Fisher-induced affine space, yielding to the discovery of a stratification of the patients into groups characterized by significantly different mortality risks following induction therapy in AML. The proposed model is shown to be able to cluster the input data, while promoting specificity of both target outcomes, namely Complete Remission (CR) and Induction Death (ID). This generic clustering methodology generates an affine transformation of the data space that is coherent with the prognostic information predicted by the PLANNCR-ARD model.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}